Transcranial Doppler Ultrasonography in the Management of Neonatal Hydrocephalus
نویسندگان
چکیده
The pathophysiological changes of progressive neonatal hydrocephalus include: increased intracranial volume of cerebrospinal fluid, progressive dilatation of cerebral ventricles, decreased intracranial compliance, raised intracranial pressure, alteration of cerebral circulation and subsequent secondary brain tissue damage (decreased cerebral blood flow, hypoperfusion, ischaemia), alteration of energy metabolism (tissue acidosis, higher lactate concentration), changes in neurotransmiter systems, damage of white matter, associative tracts and cerebral cortex. The primary target of injury are periventricular axons and myelin. Secondary changes in neurons reflect the compensation to the stress or ultimately the disconnection (De Riggo et al., 2007).
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